I don't see much use of any of the Empower Self cards.
Most Mystics will prefer to use their willpower since it's likely to be their highest stat, plus it takes up a highly coveted Arcane slot.
I can see it appearing in a Werewolf Diana Stanley deck, particularly in the Eldritch Knight variant.
Outside of Mystics I doubt Patrice Hathaway can truly capitalize with her low ,, and , particularly on higher difficulties.
Sefina Rousseau is plagued by the same limitations, while also having it compete with Double, Double (4), Borrowed Time (3), and Suggestion (4) for the Arcane slot.
Intriguingly, I can see a support Daisy Walker taking this, with limited competition for her Arcane slots and ability to maximize its utility combining with Encyclopedia (2), Strange Solution (4)
Norman Withers might be able to make use of Empower Self: Acuity, but the not much of the others. Besides, I'd prefer to use Scrying (3) as well as Shrivelling (5)/Mists of R'lyeh (4) on the Arcane slot over Empower Selves.
Did I miss out on any investigator who is able to pick up Empower Selves?
Or any combinations that maximizes its utility?