
This is a very situational card, as unlike something like Blinding Light or Bind Monster, you need to spend two full actions to evade the enemy (one to play Handcuffs, and another to use its Evade ability). In addition, it only works on Humanoid enemies. Given most campaign's tendencies to bounce between scenarios with a lot of humans and little/none at all, it's hard to justify, with the notable exceptions of The Circle Undone & Murder at the Excelsior Hotel. Even in Circle Undone I only put one in my most recent deck, but if you're a low-agility character going into it like Leo Anderson, Joe Diamond, or Roland Banks and your team doesn't already have a good way to evade enemies, it may surprise you and be the best card in your deck for a scenario or two!
Another minor thing to mention is that this can be a great enabler for a few cards like Interrogate, Scene of the Crime, and Eavesdrop - with Interrogate & Scene you can engage and drag the enemy around with you (while taking no attacks), whereas Eavesdrop will only work for the location that you originally handcuffed them since it references an unengaged enemy rather than an exhausted one.